DOXNEED

Description

Doxylamine Succinate 10 mg + Folic Acid 2.5 mg + Pyridoxine HCl 10 mg

This fixed-dose combination is primarily indicated for the treatment and management of nausea and vomiting during pregnancy (NVP), commonly known as morning sickness. It is considered a first-line therapy when dietary and lifestyle modifications are insufficient.

• Doxylamine Succinate (10 mg):
  An H1-antihistamine with sedative properties, doxylamine acts centrally to reduce nausea and vomiting by antagonizing histamine receptors in the brain’s vomiting center. It helps alleviate symptoms without harming the fetus and is well tolerated in pregnancy.

• Folic Acid (2.5 mg):
  A water-soluble B-vitamin essential for DNA synthesis and cellular growth, folic acid plays a critical role in neural tube formation during early fetal development. Adequate folic acid intake significantly reduces the risk of neural tube defects such as spina bifida and anencephaly.

• Pyridoxine Hydrochloride (Vitamin B6, 10 mg):
  Vitamin B6 is involved in amino acid metabolism and neurotransmitter synthesis. It has been shown to reduce the severity of nausea and vomiting in pregnancy by modulating neurotransmitter activity in the central nervous system.

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Clinical Indications:

• Management of Mild to Moderate Nausea and Vomiting of Pregnancy:
  Used to reduce the frequency and severity of vomiting episodes and improve quality of life during early pregnancy.

• Prevention of Neural Tube Defects:
  Folic acid supplementation before conception and during early pregnancy helps prevent major congenital malformations of the brain and spinal cord.

• Adjunctive Therapy in Hyperemesis Gravidarum:
  May be used alongside other treatments for severe vomiting when appropriate, under medical supervision.

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Dosage & Administration:

Typically administered orally as prescribed by a healthcare professional. The combination is generally safe for use during the first trimester under medical guidance.

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Safety Profile:

• Classified as pregnancy category A by FDA for folic acid and category B for doxylamine and pyridoxine, indicating no evidence of risk in humans when used as directed.

• Side effects are generally mild and may include drowsiness due to the antihistamine component.

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Summary:

This combination therapy offers a balanced approach by targeting nausea and vomiting symptoms while ensuring essential micronutrient supplementation critical for fetal neural development and maternal health.